Anti -Neurofibromin Rabbit pAb

價(jià)格：在線咨詢

貨號：

DRF101236

產(chǎn)品規(guī)格：

100 μL

Applications：

WB/IHC/IF

Species：

H/M/R,H/M/R,H/M/R

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Neurofibromin rabbit polyclonal
Protein full name	Neurofibromin
Synonyms	Neurofibromatosis-related protein NF-1, Nf1, Neurofibromin, neurofibromin 1, NFNS, VRNF, WSS
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Neurofibromin
Isotype	IgG
Purity	Affinity purification
Predicted MW.	320 kDa
Observed MW.	320 kDa
Subcellular location	Nucleus
Uniprot ID	P21359, Q04690, P97526

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Mouse, Rat	1: 500-1: 1000	lung
IHC	Human, Mouse, Rat	1: 1500-1: 4000	brain, lung, kidney, colon, testis, ovary
IF	Human, Mouse, Rat	1: 750-1: 1500	brain, lung, kidney, colon, testis, ovary

Background

Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity. Besides JMML, defects in NF1 have also been linked to neurofibromatosis type 1 (NF1), Watson syndrome (WS), familial spinal neurofibromatosis (FSNF), neurofibromatosis-Noonan syndrome (NFNS), colorectal cancer (CRC).

Images

	Western blot analysis of Neurofibromin (GB111112) at dilution of 1: 1000 Lane 1: Hela cell lysate Lane 2: Mouse lung tissue lysate Lane 3: Rat lung tissue lysate
	Immunohistochemistry analysis of paraffin-embedded mouse brain using Neurofibromin (GB111112) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded mouse lung using Neurofibromin (GB111112) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded rat kidney using Neurofibromin (GB111112) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded mouse colon using Neurofibromin (GB111112) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded mouse testis using Neurofibromin (GB111112) at dilution of 1: 3000
	Immunohistochemistry analysis of paraffin-embedded rat ovary using Neurofibromin (GB111112) at dilution of 1: 2000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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