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Anti -AMPK gamma 1 Rabbit pAb
價(jià)格：
在線(xiàn)咨詢(xún)
貨號(hào)：
DRF101212
產(chǎn)品規(guī)格：
100 μL
Applications：
WB
Species：
M/R
購(gòu)買(mǎi)數(shù)量：
產(chǎn)品詳情
操作說(shuō)明
注意事項(xiàng)
Product Information
|
Description |
AMPK gamma 1 rabbit polyclonal |
|
Protein full name |
5'-AMP-activated protein kinase subunit gamma-1 |
|
Synonyms |
AMPK gamma1, AMPK subunit gamma-1, AMPKg, Prkag1, Prkaac |
|
Immunogen |
Recombinant protein corresponding to Mouse AMPK gamma 1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
38 kDa |
|
Observed MW. |
38 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
heart, brain, muscle |
Background
AMP/ATP-binding subunit of AMP-activated protein kinase, an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive .
Images
|
|
Western blot analysis of AMPK gamma 1 (GB111090) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥萬(wàn)物生物科技有限公司
客服熱線(xiàn)：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區(qū)黃山路602號(hào)合肥國(guó)家大學(xué)科技園A401室