Anti -MLK4 Rabbit pAb

價格：在線咨詢

貨號：

DRF101193

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

M/R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	MLK4 rabbit polyclonal
Protein full name	Mitogen-activated protein kinase kinase kinase 21
Synonyms	Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4, Map3k21, Kiaa1804, Mlk4
Immunogen	Recombinant protein corresponding to Mouse MLK4
Isotype	IgG
Purity	Affinity purification
Predicted MW.	110 kDa
Observed MW.	120 kDa
Uniprot ID	Q8VDG6, D4A454

Applications

Applications	Species	Dilution	Positive Tissue
WB	Mouse, Rat	1: 500-1: 1000	heart

Background

MLK4 belongs to the MAP kinase subfamily. The MLK family members are characterized by the presence of signature sequences of Ser/Thr and Tyr kinases within their catalytic domain. The MLK1-4 contains an aminoterminal Src-Homology (SH3) domain, followed by the kinase domain, a leucine-zipper region, and a Cdc42/Rac-interactive binding (CRIB) motif. MLK4 expressed in two splicing variants, MLK4α and MLK4β. The difference of these two isoforms is located in their C-terminal portion. The negative effect of MLK4 on LPS-induced ERK and JNK activation could be very important in controlling the level of cytokine expression, and thus maintaining the balance of inflammatory responses.

Images

Western blot analysis of MLK4 (GB111071) at dilution of 1: 1000
Lane 1: Mouse heart tissue lysate
Lane 2: Rat heart tissue lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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