Anti -Polycystin 1/PC1 Rabbit pAb

價(jià)格：在線咨詢

貨號：

DRF101134

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Polycystin 1 rabbit polyclonal
Protein full name	Polycystin-1
Synonyms	PC1, Autosomal dominant polycystic kidney disease 1 protein, PKD1, PBP, PKD, PKD1, Polycystin 1 Precursor
Immunogen	Recombinant protein corresponding to Mouse Polycystin 1
Isotype	IgG
Purity	Affinity purification
Predicted MW.	463 kDa
Observed MW.	>460 kDa
Uniprot ID	P98161

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human	1: 500-1: 1000	HEK293, NIH/3t3, PC12, HCT116, SW480

Background

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. Involved in renal tubulo genesis. Involved in fluid-flow mechano sensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene.

Images

Western blot analysis of Polycystin 1 (GB111019) at dilution of 1: 800

Lane 1: HEK293 cell lysate

Lane 2: NIH/3t3 cell lysate

Lane 3: PC12 cell lysate

Lane 4: HCT116 cell lysate

Lane 5: SW480 cell lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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