Anti -MAdCAM1 Rabbit pAb

價(jià)格：在線咨詢

貨號：

DRF101121

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

H/M/R,H/M/R

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	MAdCAM1 rabbit polyclonal
Protein full name	Mucosal addressin cell adhesion molecule 1
Synonyms	MAdCAM-1, mMAdCAM-1, Madcam1, Addressin mucosal, hMAdCAM 1, MACAM1, Mucosal vascular addressin cell adhesion molecule 1
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse MAdCAM1
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cell Membrane
Uniprot ID	Q61826, O70540

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Human, Mouse, Rat	1: 1000-1: 3000	small intestine, colon, pancreas
IF	Human, Mouse, Rat	1: 500-1: 3000	small intestine, colon, pancreas

Background

MAdCAM-1 is an immunoglobulin (Ig) cell adhesion molecule family member. MAdCAM-1 is involved in lymphocyte homing to mucosal sites and is expressed on high endothelial venules (HEV) of both mesenteric lymph nodes and Peyer’s patches. It has also been found to be expressed on sinus-lining cells of the spleen. The integrin, alpha 4 beta 7, has been shown to function as the MAdCAM-1 receptor. The Ig domains of MAdCAM-1 have been found to be critical to alpha 4 beta 7 binding. The mucin domain has been shown to have activity in L-Selectin binding. MAdCAM-1 expression has been demonstrated to be up-regulated by TNF-alpha and IL-1 beta. MAdCAM-1 appears to play a role in inflammatory bowel disease (IBD) as its expression is highly up-regulated in IBD and most likely serves to recruit alpha 4 beta 7-expressing lymphocytes to the region. MAdCAM-1/ alpha 4 beta 7 interaction plays a role in diabetes development in this model.

Images

	Immunohistochemistry analysis of paraffin-embedded mouse small intestine using MAdCAM1 (GB111006) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded rat colon using MAdCAM1 (GB111006) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded rat pancreas using MAdCAM1 (GB111006) at dilution of 1: 2000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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