Anti -Caspase-3 Rabbit pAb

價(jià)格：在線咨詢

貨號：

DRF10149

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IHC

Species：

H/R,H/R

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Caspase-3 rabbit polyclonal
Protein full name	Caspase-3
Synonyms	Casp3, CASP3, CPP32, CPP32B, SCA-1, Caspase 3
Immunogen	Recombinant protein corresponding to Mouse Caspase3
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm
Uniprot ID	P42574, P70677, P55213

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Human, Rat	1: 100-1: 200	breast cancer, liver cancer, colon cancer
IHC	Human, Rat	1: 100-1: 200	breast cancer, liver cancer, colon cancer

Background

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.

Images

	Immunohistochemistry analysis of paraffin-embedded human breast cancer using Caspase-3 (GB11009-1) at dilution of 1: 200
	Immunohistochemistry analysis of paraffin-embedded human liver cancer using Caspase-3 (GB11009-1) at dilution of 1: 200
	Immunohistochemistry analysis of paraffin-embedded human colon cancer using Caspase-3 (GB11009-1) at dilution of 1: 200

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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