Anti -p115-RhoGEF Rabbit pAb

價格：在線咨詢

貨號：

KT012275

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

H/M/R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	p115-RhoGEF rabbit polyclonal antibody
Protein full name	Rho guanine nucleotide exchange factor 1
Synonyms	Lbc's second cousin, Lymphoid blast crisis-like 2, Arhgef1, Lbcl2, Lsc, p115RhoGEF, GEF1, LBCL2LSC
Immunogen	Recombinant protein corresponding to Mouse p115-RhoGEF
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm, Membrane
Uniprot ID	Q92888, Q61210, Q9Z1I6

Applications

Applications	Species	Dilution	Positive Sample
IHC/IF	Human, Mouse, Rat	1: 500-1: 4000	lymph node, spleen, thymus, thyroid gland

Background

This protein seems to play a role in the regulation of RhoA GTPase by guanine nucleotide binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

Images

	Immunohistochemistry of paraffin embedded human thyroid gland using Arhgef1 at dilution of 1:2000 (400x lens)
	Immunohistochemistry of paraffin embedded mouse lymph node using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens)
	Immunohistochemistry of paraffin embedded mouse spleen using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens)
	Immunohistochemistry of paraffin embedded mouse thymus using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens)
	Immunohistochemistry of paraffin embedded rat lymph node using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens)
	Immunohistochemistry of paraffin embedded rat spleen using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens)
	Immunofluorescence of paraffin embedded human lymph node using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens)
	Immunofluorescence of paraffin embedded human thyroid gland using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens)
	Immunofluorescence of paraffin embedded mouse lymph node using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens)
	Immunofluorescence of paraffin embedded rat spleen using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens)
	Immunofluorescence of paraffin embedded rat thymus using Arhgef1 (GB111024) at dilution of 1:2000 (400x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

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