Anti -Exportin 4/XPO4 Rabbit pAb

價(jià)格：在線咨詢

貨號：

KT012167

產(chǎn)品規(guī)格：

100ul

Applications：

Species：

M/R

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Exportin 4/XPO4 rabbit polyclonal antibody
Protein full name	Exportin-4
Synonyms	Exp4, Xpo4, Kiaa1721
Immunogen	Recombinant protein corresponding to Mouse Exportin 4/XPO4
Isotype	IgG
Purity	Affinity purification
Predicted MW.	130 kDa
Observed MW.	130 kDa
Uniprot ID	Q9ESJ0

Applications

Applications	Species	Dilution	Positive Sample
WB	Mouse, Rat	1: 1000-1: 2000	thymus

Background

XPO4 belongs to a large family of karyopherins that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments . In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Images

Western blot analysis of Xpo4 (GB112617) at dilution of 1: 1000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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