Anti -NEDD4 Rabbit pAb

價(jià)格：在線咨詢

貨號：

KT011934

產(chǎn)品規(guī)格：

100ul

Applications：

Species：

M/R

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	NEDD4 rabbit polyclonal antibody
Protein full name	E3 ubiquitin-protein ligase NEDD4
Synonyms	HECT-type E3 ubiquitin transferase NEDD4, Kiaa0093, Neural precursor cell expressed developmentally down-regulated protein 4, Nedd4, Nedd4-1, Nedd4a
Immunogen	Recombinant protein corresponding to Mouse NEDD4
Isotype	IgG
Purity	Affinity purification
Predicted MW.	103 kDa
Observed MW.	120 kDa
Uniprot ID	P46935, Q62940

Applications

Applications	Species	Dilution	Positive Tissue
WB	Mouse, Rat	1: 500-1: 1000	brain, lung, cerebral cortex

Background

The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/kDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.

Images

Picture 1.png

Western blot analysis of nedd4 (GB111057) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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