Anti -Neurofibromin Rabbit pAb

價格：在線咨詢

貨號：

KT011584

產(chǎn)品規(guī)格：

100ul

Applications：

WB/IHC/IF

Species：

H/M/R,H/M/R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	Neurofibromin rabbit polyclonal antibody
Protein full name	Neurofibromin
Synonyms	Neurofibromatosis-related protein NF-1, Nf1, Neurofibromin, neurofibromin 1, NFNS, VRNF, WSS
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Neurofibromin
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus
Predicted MW.	320 kDa
Observed MW.	320 kDa
Uniprot ID	P21359, Q04690, P97526

Applications

Applications	Species	Dilution	Positive Sample
WB	Human, Mouse, Rat	1: 500-1: 1000	lung
IHC/IF	Human, Mouse, Rat	1: 750-1: 4000	brain, breast cancer, colon, lung, ovary, Skeletal muscle, testis

Background

Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity.

Images

	Western blot analysis of Neurofibrmin-1 (GB111112) at dilution of 1: 500
	Immunohistochemistry of paraffin embedded mouse brain using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)
	Immunohistochemistry of paraffin embedded mouse colon using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)
	Immunohistochemistry of paraffin embedded mouse lung using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)
	Immunohistochemistry of paraffin embedded rat colon using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)
	Immunohistochemistry of paraffin embedded rat lung using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)
	Immunohistochemistry of paraffin embedded rat skeletal muscle using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)
	Immunofluorescence of paraffin embedded human breast cancer using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens)
	Immunofluorescence of paraffin embedded mouse brain using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens)
	Immunofluorescence of paraffin embedded mouse ovary using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens)
	Immunofluorescence of paraffin embedded rat testis using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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