Anti -Metabotropic Glutamate Receptor 4/MGLUR4 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

KT011488

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

M,R

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Metabotropic Glutamate Receptor 4/MGLUR4 rabbit polyclonal antibody
Protein full name	Metabotropic glutamate receptor 4
Synonyms	Glutamate receptor metabotropic 4, GPRC1D, Grm4, Metabotropic glutamate receptor 4, mGluR4, mGlu4
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Metabotropic Glutamate Receptor 4/MGLUR4
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cell membrane
Uniprot ID	Q68EF4

Applications

Applications	Species	Dilution	Positive Sample
IHC/IF	Mouse, Rat	1: 1000-1: 2000	striatum, brain

Background

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

Images

	Immunohistochemistry of paraffin embedded mouse striatum using GRM4 (GB113895) at dilution of 1: 2000 (200x lens
	Immunohistochemistry of paraffin embedded rat brain using GRM4 (GB113895) at dilution of 1: 1500 (200x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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