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Anti -Glutamine Synthetase Rabbit pAb

價格: 在線咨詢
貨號:
KT011461
產(chǎn)品規(guī)格:
100 μL
Applications:
WB
Species:
M,R
購買數(shù)量:
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產(chǎn)品詳情 操作說明 注意事項

Product Information


Description

Glutamine Synthetase rabbit polyclonal antibody

Protein full name

Glutamine synthetase

Synonyms

GS, Glutamate--ammonia ligase, GLUL, Palmitoyltransferase GLUL, GLNS

Immunogen

Recombinant protein corresponding to Human Glutamine Synthetase

Isotype

IgG

Purity

Affinity purification

Predicted MW.

42 kDa

Observed MW.

42 kDa

Uniprot ID

P15105, P09606




Applications


Applications

Species

Dilution

Positive Sample

WB

Mouse, Rat

1: 500-1: 1000

brain, testis




Background


Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. It is found in astrocytes as an octamer of identical 42 kDa subunits. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in the metabolic regulation of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture.




Images


Picture 1.png

Western blot analysis of GluL (GB111217) at dilution of 1: 500




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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