Anti -NCR1 Rabbit pAb

價格：在線咨詢

貨號：

DRF101625

產品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數量：

立即詢價在線咨詢 400-1016-218

產品詳情操作說明注意事項

Product Information

Description	NCR1 rabbit polyclonal
Protein full name	Natural cytotoxicity triggering receptor 1
Synonyms	Activating receptor 1, mAR-1, Lymphocyte antigen 94, Natural killer cell p46-related protein, NK-p46, NKp46, CD335, Ncr1, Ly94
Immunogen	Recombinant protein corresponding to Mouse NCR1
Isotype	IgG
Purity	Affinity purification
Predicted MW.	37 kDa
Observed MW.	46 kDa
Uniprot ID	Q8C567, Q9Z0H5

Applications

Applications	Species	Dilution	Positive Tissue
WB	Mouse, Rat	1: 500-1: 1000	spleen, thymus, lymph gland

Background

NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR) . These receptors are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. Mouse NKp46, also known as MAR-1 is a type I trans membrane protein with two extracellular Ig-like domains. It has a positive charge in its transmembrane domain that permits association with the ITAM-bearing signal adapter proteins, CD3 zeta and Fc epsilon RI gamma. Studies with neutralizing antibodies indicate that the three NCR are primarily responsible for triggering the NK-mediated lysis of many human tumor cell lines. Blocking any of the NCRs individually resulted in partial inhibition of tumor cell lysis, but nearly complete inhibition of lysis was observed if all three receptors were blocked simultaneously. NKp46 has also been implicated in recognition of virus-infected cells through its capacity to bind to viral hemagglutinins.

Images

IWestern blot analysis of NCR1 (GB111102) at dilution of 1: 1000
Lane 1: A549 cell lysate
Lane 2: RAW264.7 cell lysate
Lane 3: Jurkat cell lysate
Lane 4: Mouse spleen tissue lysate
Lane 5: Mouse thymus tissue lysate
Lane 6: Mouse lymph gland tissue lysate
Lane 7: Rat spleen tissue lysate
Lane 8: Rat thymus tissue lysate
Lane 9: Rat lymph gland tissue lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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