Anti -SQSTM1/p62 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

KT012189

產(chǎn)品規(guī)格：

100 μL

Applications：

WB | IHC | IF

Species：

H,M,R | H,M

品牌：

萬(wàn)物

購(gòu)買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說(shuō)明注意事項(xiàng)

Product Information

Description	P62 rabbit polyclonal antibody
Protein full name	Sequestosome-1
Synonyms	SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, Sequestosome 1, NADGP, DMRV
Immunogen	Recombinant protein corresponding to Mouse P62
Isotype	IgG
Purity	Affinity purification
Subcellular location	Late endosome, Nucleus, PML body, Lysosome, Endoplasmic reticulum, Cytoplasm, Autophagosome, Sarcomere
Predicted MW.	48 kDa
Observed MW.	62 kDa
Uniprot ID	Q13501, O08623, Q64337

Applications

Applications	Species	Dilution	Positive Sample
WB	Human, Mouse, Rat	1:500-1:1500	kidney
ICC/IF	Human, Mouse	1:1000-1: 2000	HeLa, NIH/3T3

Background

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family . Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells.

Images

	Western blot analysis of SQSTM1 p62 (GB11239-1) at dilution of 1: 500
	Immunocytochemistry analysis of 4% paraformaldehyde-fixed Hela cell untreatd using p62 (GB11239-1) at dilution of 1: 1000
	Immunocytochemistry analysis of 4% paraformaldehyde-fixed Hela cell with chloroquine treated using p62 (GB11239-1) at dilution of 1: 1000
	Immunocytochemistry analysis of 4% paraformaldehyde-fixed NIH/3T3 cell with chloroquine treated (above) and untreatd (below) using P62 (GB11239-1) at dilution of 1: 2000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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