Anti -Cyclin D1 Rabbit pAb

價格：在線咨詢

貨號：

KT011782

產(chǎn)品規(guī)格：

100 μL

Applications：

WB | IHC

Species：

H,M,R | M,R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	Cyclin D1 rabbit polyclonal
Protein full name	G1/S-specific cyclin-D1
Synonyms	CCND1, BCL1, D11S287E, PRAD1, U21B31, cyclin D1
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Cyclin D1
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm, Nucleus
Predicted MW.	33 kDa
Observed MW.	33 kDa
Uniprot ID	P25322, P39948

Applications

applications	species	dilution	Positive tissue
WB	Human, Mouse,Rat	1: 300-1: 800	MCF7, HeLa, LnCap, SH-SY5Y, PC12, A431
IHC	Mouse,Rat	1: 600-1: 1200	skin, esophagus, colon, stomach

Background

The protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDKs (Cyclin-dependent kinase). Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb.

Images

	Western blot analysis of Cyclin D1 (GB111372) at dilution of 1: 800 Lane 1: MCF7 cell lysate Lane 2: HeLa cell lysate Lane 3: LnCap cell lysate Lane 4: SH-SY5Y cell lysate Lane 5: PC12 cell lysate Lane 6: A431 cell lysate
	Immunohistochemistry analysis of paraffin-embedded mouse skin using Cyclin D1 (GB111372) at dilution of 1: 600
	Immunohistochemistry analysis of paraffin-embedded mouse esophagus using Cyclin D1 (GB111372) at dilution of 1: 600
	Immunohistochemistry analysis of paraffin-embedded mouse colon using Cyclin D1 (GB111372) at dilution of 1: 600
	Immunohistochemistry analysis of paraffin-embedded rat colon using Cyclin D1 (GB111372) at dilution of 1: 600
	Immunohistochemistry analysis of paraffin-embedded mouse stomach using Cyclin D1 (GB111372) at dilution of 1: 600
	Immunohistochemistry analysis of paraffin-embedded rat stomach using Cyclin D1 (GB111372) at dilution of 1: 600

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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