Anti -Chk1 Rabbit pAb

價格：在線咨詢

貨號：

KT011716

產(chǎn)品規(guī)格：

Applications：

IHC

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Chk1 rabbit polyclonal antibody
Protein full name	Serine/threonine-protein kinase Chk1
Synonyms	CHK1 checkpoint homolog, Checkpoint kinase-1, Chek1, Chk1
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Chk1
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus, Cytoplasm
Uniprot ID	Q91ZN7

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Rat	1: 600-1: 1300	lung, spleen, brain

Background

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks.

Images

	Immunohistochemistry of paraffin embedded rat brain using CHK1 (GB111146) at dilution of 1:650 (400x lens)
	Immunohistochemistry of paraffin embedded rat lung using CHK1 (GB111146) at dilution of 1:650 (400x lens)
	Immunohistochemistry of paraffin embedded rat spleen using CHK1 (GB111146) at dilution of 1:650 (400x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer.

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