Anti -PARK7/DJ1 Rabbit pAb

價格：在線咨詢

貨號：

KT011655

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

HMR

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	PARK7/DJ1 rabbit polyclonal antibody
Protein full name	Protein/nucleic acid deglycase DJ-1
Synonyms	PARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2
Immunogen	Recombinant protein corresponding to Mouse PARK7
Isotype	IgG
Purity	Affinity purification
Predicted MW.	20 kDa
Observed MW.	24 kDa
Uniprot ID	Q99LX0, Q99497, O88767

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Mouse, Rat	1: 500-1: 1000	brain, liver, kidney

Background

Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus functions as a redox-sensitive chaperone and as a sensor for oxidative stress. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death. In parallel, Protein DJ-1 acts as a positive regulator of androgen receptor-dependent transcription. Pyrroloquinoline quinone (PQQ) has been shown to reduce the self-oxidation of the DJ-1 protein, an early step in the onset of some forms of Parkinson's disease. Functional DJ-1 protein has been shown to bind metals and protect against metal-induced cytotoxicity from copper and mercury.

Images

Western blot analysis of DJ-1 (GB11597) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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