Anti -CD74 Rabbit pAb

價格：在線咨詢

貨號：

DRF101822

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項

Product Information

Description	CD74 rabbit polyclonal
Protein full name	H-2 class II histocompatibility antigen gamma chain
Synonyms	Ia antigen-associated invariant chain, Ii, MHC class II-associated invariant chain, CD74
Immunogen	Recombinant protein corresponding to Mouse CD74
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cell Membrane
Uniprot ID	P04441, P10247

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1:1000-1:4000	lymphoid, spleen, immune spleen
IF	Mouse, Rat	1:500-1:1000

Background

CD74, also known as the MHC class II associated invariant chain (Ii), is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is produced in molar excess over MHC class II and some of this is expressed by an unknown pathway on the cell surface independent of or in association with MHC class II molecules. The half life of CD74 on the cell surface is only 3 to 4 min after which it is internalized. It has been proposed that cell surface CD74 binds MHC class II molecules which have lost their antigenic peptide leading to internalization and reloading with antigenic peptide. The transport route of class II alpha/beta/Ii complexes is regulated selectively by two forms of CD74 (p33 and p35) which are generated by the use of alternative translation initiation sites. CD74 is expressed primarily by antigen presenting cells such as B lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages and monocytes together, with many epithelial cells.

Images

	Immunohistochemistry analysis of paraffin-embedded mouse spleen using CD74 (GB111179) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded mouse immune spleen using CD74 (GB111179) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded mouse lymphoid using CD74 (GB111179) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded rat lymphoid using CD74 (GB111179) at dilution of 1: 2000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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