Anti -MDA5 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

DRF101745

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬(wàn)物

購(gòu)買數(shù)量：

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產(chǎn)品詳情操作說(shuō)明注意事項(xiàng)

Product Information

Description	MDA5 rabbit polyclonal
Protein full name	Interferon-induced helicase C domain-containing protein 1
Synonyms	Helicase with 2 CARD domains, Helicard, Melanoma differentiation-associated protein 5, MDA-5, RIG-I-like receptor 2, RLR-2, Ifih1, RH116, MDA5
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse MDA5
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm, Nucleus
Uniprot ID	Q8R5F7

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1: 300-1: 600	liver, kidney, heart
IF	Mouse, Rat	1: 300-1: 600	lung, kidney longitudinal

Background

IFIH1 (Interferon-induced helicase C domain-containing protein 1) is a putative RNA helicase that is upregulated in response to treatment with IFNB or IFNB and MEZ. It is also named as MDA5 and RH116. Ectopic expression of MDA5 in melanoma cells resulted in reduced colony formation, suggesting an interaction of the CARD and apoptotic signal molecules. Functional analysis indicated that MDA5 is an RNA-dependent ATPase. IFIH1 has an apparent molecular mass of 117-130 kDa, and always other bands (70 kDa and 90 kDa) can be detected as cleaved products.

Images

	Immunohistochemistry analysis of paraffin-embedded mouse liver using MDA5 (GB111891) at dilution of 1: 600
	Immunohistochemistry analysis of paraffin-embedded mouse kidney using MDA5 (GB111891) at dilution of 1: 600
	Immunohistochemistry analysis of paraffin-embedded mouse heart using MDA5 (GB111891) at dilution of 1: 600
	Immunofluorescent analysis of paraformaldehyde-fixed mouse lung using MDA5 (GB111891) at dilution of 1: 600
	Immunofluorescent analysis of paraformaldehyde-fixed mouse kidney longitudinal using MDA5 (GB111891) at dilution of 1: 600

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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